Dr. Antonio Iavarone Publications

Biography
Research Summary
Publications
Lab Members

Recent Publications

  1. Rajbhandari P, Lopez G, Capdevila C, Salvatori B, Yu J, Rodriguez-Barrueco R, Martinez D, Yarmarkovich M, Weichert-Leahey N, Abraham BJ, Alvarez MJ, Iyer A, Harenza JL, Oldridge D, De Preter K, Koster J, Asgharzadeh S, Seeger RC, Wei JS, Khan J, Vandesompele J, Mestdagh P, Versteeg R, Look AT, Young RA, Iavarone A, Lasorella A, Silva JM, Maris JM, Califano A. Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma. Cancer Discov. 2018 May;8(5):582-599

  2. Frattini V, Pagnotta SM, Tala, Fan JJ, Russo MV, Lee SB, Garofano L, Zhang J, Shi P, Lewis G, Sanson H, Frederick V, Castano AM, Cerulo L, Rolland DCM, Mall R, Mokhtari K, Elenitoba-Johnson KSJ, Sanson M, Huang X, Ceccarelli M, Lasorella A, Iavarone A. A metabolic function of FGFR3-TACC3 gene fusions in cancer. Nature. 2018 Jan 11;553(7687):222-227

  3. Lee JK, Wang J, Sa JK, Ladewig E, Lee HO, Lee IH, Kang HJ, Rosenbloom DS, Camara PG, Liu Z, van Nieuwenhuizen P, Jung SW, Choi SW, Kim J, Chen A, Kim KT, Shin S, Seo YJ, Oh JM, Shin YJ, Park CK, Kong DS, Seol HJ, Blumberg A, Lee JI, Iavarone A, Park WY, Rabadan R, Nam DH. Spatiotemporal genomic architecture informs precision oncology in glioblastoma. Nat Genet. 2017 Apr; 49(4):594-599

  4. Lasorella A, Sanson M, Iavarone A. FGFR-TACC gene fusions in human glioma. Neuro Oncol. 2017 Apr 1;19(4):475-483

  5. Wang J, Cazzato E, Ladewig E, Frattini V, Rosenbloom DI, Zairis S, Abate F, Liu Z, Elliott O, Shin YJ, Lee JK, Lee IH, Park WY, Eoli M, Blumberg AJ, Lasorella A, Nam DH, Finocchiaro G, Iavarone A, Rabadan R. Clonal evolution of glioblastoma under therapy. Nat Genet. 2016 Jul;48(7):768-76

  6. Lee SB, Frattini V, Bansal M, Castano AM, Sherman D, Hutchinson K, Bruce JN, Califano A, Liu G, Cardozo T, Iavarone A, Lasorella A. An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 2016 Jan 14;529(7585):172-7

  7. Di Stefano AL, Fucci A, Frattini V, Labussiere M, Mokhtari K, Zoppoli P, Marie Y, Bruno A, Boisselier B, Giry M, Savatovsky J, Touat M, Belaid H, Kamoun A, Idbaih A, Houillier C, Luo FR, Soria JC, Tabernero J, Eoli M, Paterra R, Yip S, Petrecca K, Chan JA, Finocchiaro G, Lasorella A, Sanson M, Iavarone A. Detection, Characterization, and Inhibition of FGFR-TACC Fusions in IDH Wild-type Glioma. Clin Cancer Res. 2015 Jul 15;21(14):3307-17

  8. Iavarone A, Lasorella A. Myc and differentiation: going against the current. EMBO Rep. 2014 Apr 1;15(4):324-5.

  9. Lasorella A, Benezra R, Iavarone A. The ID proteins: master regulators of cancer stem cells and tumour aggressiveness. Nat Rev Cancer. 2014 Feb;14(2):77-91.

  10. Frattini V, Trifonov V, Chan JM, Castano A, Lia M, Abate F, Keir ST, Ji AX, Zoppoli P, Niola F, Danussi C, Dolgalev I, Porrati P, Pellegatta S, Heguy A, Gupta G, Pisapia DJ, Canoll P, Bruce JN, McLendon RE, Yan H, Aldape K, Finocchiaro G, Mikkelsen T, Privé GG, Bigner DD, Lasorella A, Rabadan R, Iavarone A. The integrated landscape of driver genomic alterations in glioblastoma. Nat Genet. 2013 Oct;45(10):1141-9.

  11. Singh D, Chan JM, Zoppoli P, Niola F, Sullivan R, Castano A, Liu EM, Reichel J, Porrati P, Pellegatta S, Qiu K, Gao Z, Ceccarelli M, Riccardi R, Brat DJ, Guha A, Aldape K, Golfinos JG, Zagzag D, Mikkelsen T, Finocchiaro G, Lasorella A, Rabadan R, Iavarone A. Transforming fusions of FGFR and TACC genes in human glioblastoma. Science. 337, 1231‐5,2012.

  12. Niola F, Zhao X, Singh D, Castano A, Sullivan R, Lauria M, Nam HS, Zhuang Y, Benezra R, Di Bernardo D, Iavarone A, Lasorella A. Id proteins synchronize stemness and anchorage to the niche of neural stem cells. Nature Cell Biology 14(5): 477‐87, 2012.

  13. Barrett LE, Granot Z, Coker C, Iavarone A, Hambardzumyan D, Holland EC, Nam HS, Benezra R. Self‐renewal does not predict tumor growth potential in mouse models of high‐grade glioma. Cancer Cell 21; 11‐24, 2012.

  14. Jones‐Mason ME, Zhao X, Kappes D, Lasorella A, Iavarone A, Zhuang Y. E protein transcription factors are required for the development of CD4(+) lineage T cells. Immunity 36(3):348‐61, 2012.

  15. Coma S., Amin D. N., Shimizu A., Lasorella A., Iavarone A. and Klagsbrun M. Id2 promotes tumor cell migration and invasion through transcriptional repression of Semaphorin 3F. Cancer Res. 70(9): 3823‐32, 2010.

  16. D’Arca D., Zhao X., Xu W., Ramirez‐Martinez N., Iavarone A., and Lasorella A. The Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum. Proc. Natl. Acad. Sci. U S A. 107(13): 5875‐80, 2010.

  17. Carro M.S., Lim W.K., Alvarez M.J., Bollo R.J., Zhao X., Snyder E.Y., Sulman E.P., Anne S. L., Doetsch F., Colman H., Lasorella A., Aldape K., Califano A., Iavarone A. A transcriptional module synergistically initiates and maintains mesenchymal transformation in the brain. Nature (Article), 463:318‐325 2010.

  18. Zhao X., D’Arca D., Lim W.K., Brahmachary M., Carro M. S., Ludwig T., Guillemot F., Aldape K., Califano A., Iavarone A., and Lasorella A. The N‐Myc‐DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain. Developmental Cell, 17(2):210‐21, 2009.

  19. Zhao X., Heng, J., Guardavaccaro D., Jiang R., Pagano M., Guillemot F., Iavarone A., and Lasorella A. The HECT‐domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N‐Myc oncoprotein. Nat. Cell. Biol. 10 (6): 643‐653, 2008.

  20. GuardavaccaroD., Frescas D., Dorrello N.V., Peschiaroli A., Multani A.S., Cardozo T., Lasorella A., Iavarone A., Chang S., Hernando E., Pagano M., Control of chromosome stability by the beta‐TrCP‐REST‐Mad2 axis. Nature 20;452(7185):365‐369, 2008.

  21. Lasorella A., Stegmüller J., Guardavaccaro D., Liu G., Carro M.S., Rothschild G., de la Torre‐Ubieta L., Pagano M., Bonni A., Iavarone A. Degradation of Id2 by the Anaphase Promoting Complex couples cell cycle exit and axonal growth. Nature, 442:471‐474, 2006.

  22. Rothschild G., Zhao X., Iavarone A., Lasorella A. E proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells. Mol. Cell. Biol. 26:4351‐4361, 2006.

  23. Lasorella A., Rothschild G., Yokota Y., Russell R.G., and Iavarone A. Id2 mediates tumor initiation, proliferation and angiogenesis in Rb mutant mice. Mol Cell Biol. 25:3563‐74, 2005.

  24. Perk J, Iavarone A, Benezra R. Id family of helix‐loop‐helix proteins in cancer. Nature Rev. Cancer 5(8):603‐14, 20005

  25. Iavarone. A., King E.R., Xu‐Ming Dai, Leone G., Stanley E.R. Lasorella. A. Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. Nature 432: 1040‐1045, 2004.

  26. Russell RG, Lasorella A, Dettin LE, Iavarone A. Id2 drives differentiation and suppresses tumor formation in the intestinal epithelium. Cancer Res. 6:7220‐5, 2005.

  27. Lasorella A., Noseda M., Beyna M., Iavarone A. Id2 is a target of the retinoblastoma protein and mediates signalling by Myc oncoproteins. Nature (Article), 407:592‐598, 2000