Dr. Antonio Iavarone Publications

Research Summary
Lab Members

Recent Publications

1. Iavarone A, Lasorella A. Myc and differentiation: going against the current. EMBO Rep. 2014 Apr 1;15(4):324-5.

2. Lasorella A, Benezra R, Iavarone A. The ID proteins: master regulators of cancer stem cells and tumour aggressiveness. Nat Rev Cancer. 2014 Feb;14(2):77-91.

3. Frattini V, Trifonov V, Chan JM, Castano A, Lia M, Abate F, Keir ST, Ji AX, Zoppoli P, Niola F, Danussi C, Dolgalev I, Porrati P, Pellegatta S, Heguy A, Gupta G, Pisapia DJ, Canoll P, Bruce JN, McLendon RE, Yan H, Aldape K, Finocchiaro G, Mikkelsen T, Privé GG, Bigner DD, Lasorella A, Rabadan R, Iavarone A. The integrated landscape of driver genomic alterations in glioblastoma. Nat Genet. 2013 Oct;45(10):1141-9.

4. Singh D, Chan JM, Zoppoli P, Niola F, Sullivan R, Castano A, Liu EM, Reichel J, Porrati P, Pellegatta S, Qiu K, Gao Z, Ceccarelli M, Riccardi R, Brat DJ, Guha A, Aldape K, Golfinos JG, Zagzag D, Mikkelsen T, Finocchiaro G, Lasorella A, Rabadan R, Iavarone A. Transforming fusions of FGFR and TACC genes in human glioblastoma. Science. 337, 1231‐5,2012.

5. Niola F, Zhao X, Singh D, Castano A, Sullivan R, Lauria M, Nam HS, Zhuang Y, Benezra R, Di Bernardo D, Iavarone A, Lasorella A. Id proteins synchronize stemness and anchorage to the niche of neural stem cells. Nature Cell Biology 14(5): 477‐87, 2012.

6. Barrett LE, Granot Z, Coker C, Iavarone A, Hambardzumyan D, Holland EC, Nam HS, Benezra R. Self‐renewal does not predict tumor growth potential in mouse models of high‐grade glioma. Cancer Cell 21; 11‐24, 2012.

7. Jones‐Mason ME, Zhao X, Kappes D, Lasorella A, Iavarone A, Zhuang Y. E protein transcription factors are required for the development of CD4(+) lineage T cells. Immunity 36(3):348‐61, 2012.

8. Coma S., Amin D. N., Shimizu A., Lasorella A., Iavarone A. and Klagsbrun M. Id2 promotes tumor cell migration and invasion through transcriptional repression of Semaphorin 3F. Cancer Res. 70(9): 3823‐32, 2010.

9. D’Arca D., Zhao X., Xu W., Ramirez‐Martinez N., Iavarone A., and Lasorella A. The Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum. Proc. Natl. Acad. Sci. U S A. 107(13): 5875‐80, 2010.

10. Carro M.S., Lim W.K., Alvarez M.J., Bollo R.J., Zhao X., Snyder E.Y., Sulman E.P., Anne S. L., Doetsch F., Colman H., Lasorella A., Aldape K., Califano A., Iavarone A. A transcriptional module synergistically initiates and maintains mesenchymal transformation in the brain. Nature (Article), 463:318‐325 2010.

11. Zhao X., D’Arca D., Lim W.K., Brahmachary M., Carro M. S., Ludwig T., Guillemot F., Aldape K., Califano A., Iavarone A., and Lasorella A. The N‐Myc‐DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain. Developmental Cell, 17(2):210‐21, 2009.

12. Zhao X., Heng, J., Guardavaccaro D., Jiang R., Pagano M., Guillemot F., Iavarone A., and Lasorella A. The HECT‐domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N‐Myc oncoprotein. Nat. Cell. Biol. 10 (6): 643‐653, 2008.

13. GuardavaccaroD., Frescas D., Dorrello N.V., Peschiaroli A., Multani A.S., Cardozo T., Lasorella A., Iavarone A., Chang S., Hernando E., Pagano M., Control of chromosome stability by the beta‐TrCP‐REST‐Mad2 axis. Nature 20;452(7185):365‐369, 2008.

14. Lasorella A., Stegmüller J., Guardavaccaro D., Liu G., Carro M.S., Rothschild G., de la Torre‐Ubieta L., Pagano M., Bonni A., Iavarone A. Degradation of Id2 by the Anaphase Promoting Complex couples cell cycle exit and axonal growth. Nature, 442:471‐474, 2006.

15. Rothschild G., Zhao X., Iavarone A., Lasorella A. E proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells. Mol. Cell. Biol. 26:4351‐4361, 2006.

16. Lasorella A., Rothschild G., Yokota Y., Russell R.G., and Iavarone A. Id2 mediates tumor initiation, proliferation and angiogenesis in Rb mutant mice. Mol Cell Biol. 25:3563‐74, 2005.

17. Perk J, Iavarone A, Benezra R. Id family of helix‐loop‐helix proteins in cancer. Nature Rev. Cancer 5(8):603‐14, 20005

18. Iavarone. A., King E.R., Xu‐Ming Dai, Leone G., Stanley E.R. Lasorella. A. Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. Nature 432: 1040‐1045, 2004.

19. Russell RG, Lasorella A, Dettin LE, Iavarone A. Id2 drives differentiation and suppresses tumor formation in the intestinal epithelium. Cancer Res. 6:7220‐5, 2005.

20. Lasorella A., Noseda M., Beyna M., Iavarone A. Id2 is a target of the retinoblastoma protein and mediates signalling by Myc oncoproteins. Nature (Article), 407:592‐598, 2000